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 | Molecular Biology of human cancers
Book Description
Over the last three decades, knowledge on the molecular biology of human cancers has vastly expanded. A host of genes and proteins involved in cancer development and progression have been defined and many mechanisms at the molecular, cellular and even tissue level have been, at least partly, elucidated. Insights have also been gained into the molecular mechanisms underlying carcinogenesis by chemical, physical, and biological agents and into inherited susceptibility to cancer. Accordingly, Part I of the book presents many of the molecules and mechanisms generally important in human cancers. Following an overview on the cancer problem, individual chapters deal with cancer genetics and epigenetics, DNA damage and repair, oncogenes, tumor suppressors, regulatory pathways in cancer, apoptosis, cellular senescence, tumor invasion, and metastasis. A consensus is emerging that while these common mechanisms and molecules are all relevant to human cancers, in each cancer type (or even subtype) a selection of them are extremely important. For selected cancers, the route from genetic and epigenetic changes to their biological and clinical behavior can already be traced. Part II of the book presents a broad, but exemplary selection of cancers that serve as paradigms to illustrate this point. In fact, cancer research has now reached a critical stage, in which the accumulated knowledge on molecular mechanisms is gradually translated into improved prevention, diagnosis, and treatment. The state, pitfalls, and potential of these efforts are summarized in Part III. More than ever, cancer research is now an interdisciplinary effort which requires a basic knowledge of commonly used terms, facts, issues, and concepts. The aim of this book is to provide advanced students and practitioners of different disciplines with this basis, bridging the gap between standard textbooks of molecular biology, pathology, and oncology on the one hand and the specialized cancer literature on the other.
Hardcover: 508 pages
Publisher: Springer; 1 edition (April 29, 2005)
ISBN: 1402031858
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 | Musculoskeletal Cancer Surgery
is the most current surgical text describing and illustrating:
step-by-step descriptions of surgical techniques for the management of bone and soft-tissue tumors of the extremities
shoulder and pelvic girdle sarcomas
new, sophisticated, multimodality procedures for truncal and abdominal sarcomas
Many of the procedures described in this text were developed by the authors, Drs. Malawer and Sugarbaker, who have a combined surgical experience of over 50 years. This text has over 400 color illustrations and schematic drawings, in addition to imaging studies and full color intraoperative and clinical photographs.
Editors:
Martin Malawer , Paul Sugarbaker
590 pp, PDF format
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16.37 MB
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Chabner Cancer Chemotherapy & Biotherapy Principles
Bruce A. Chabner (Editor), Dan L. Longo (Editor),
Lippincott Williams & Wilkins | ISBN 0781722691 | 2001 Year | PDB | 6,4 Mb | 1140 Pages
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Harvey_ Lung Cancer - Principles and Practice
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Rosenberg Cancer - Principles & Practice of Oncology
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Rubin Ovarian Cancer
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Souhami Oxford_ Textbook of Oncology
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Bonica's Management of Pain
by John D. Loeser, Steven H. Butler, C. Richard Chapman, PhD Dennis C. Turk
Lippincott Williams & Wilkins; 3rd edition (January 15, 2001)
2178 pages, pdb file
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Advances in Cancer Research, Volume 91
Edited By George Vande Woude, Director, Van Andel Research Institute, Grand Rapids, Michigan, U.S.A.
George Klein, Karolinska Insitutet, Stockholm, Sweden
ISBN: 0-12-006691-2, 224 pages, publication date: 2004
Publisher: ACADEMIC PRESS
Description
The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including
Contents
Imatinib as a Paradigm Of Targeted Therapies; Prostate Cancer and the Met Hepatocyte Growth Factor Receptor; Keratinocyte Growth Factor (KGF/FGF7), a Homeostatic Factor with Therapeutic Potential for Epithelial Protection and Repair; Histone Deacetylase Inhibitors; Raf-1 Kinase Inhibitor Protein (RKIP): Structure, Function, Regulation of Cell Signaling and Pivotal Role in Apoptosis
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The Cancer Handbook (A Patterson Institute for Cancer Research issue), Manchester, UK | PDF | 1509 pages | 24 Mb
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The Chemotherapy Source Book
Michael C., Md. Perry (Editor), "The Chemotherapy Source Book" (3rd edition)
Lippincott Williams & Wilkins | ISBN 0781723639 | 2001 Year | PDB | 6,7 Mb | 1003 Pages
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Lippincott's Cancer Chemotherapy Handbook
Delia C. Baquiran, Jean Gallagher, "Lippincott's Cancer Chemotherapy Handbook" (2nd edition)
Lippincott Williams & Wilkins | ISBN 0781726468 | 2001 Year | PDB | 1,3 Mb | 509 Pages
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The Washington Manual of Oncology
Ramaswamy, Md. Govindan (Editor), Matthew A., MD Arquette (Editor), "The Washington Manual of Oncology"
Lippincott Williams & Wilkins | ISBN 0781730309 | 2002 Year | PDB | 2,3 Mb | 588 Pages
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Manual of Clinical Oncology
Dennis Albert Casciato (Editor), Barry Bennett Lowitz (Editor), "Manual of Clinical Oncology" (4th Spiral edition)
Lippincott Williams & Wilkins | ISBN 0781721598 | 2000 Year | PDB | 1,7 Mb | 750 Pages
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Cancer: Principles and Practice of Oncology
Vincent T. Devita, Samuel Hellman, Steven A. Rosenberg, "Cancer: Principles and Practice of Oncology" (6th edition)
Lippincott Williams & Wilkins | ISBN 0781722292 | 2001 Year | PDB | 39,6 Mb | 3235 Pages
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Encyclopedic Reference of Cancer
ISBN: 3540665277
Author: Manfred Schwab (Editor) , Publisher: Springer
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 | Cancer Immune
Therapy :Current and Future Strategies
Editorial Reviews
From the New England Journal of Medicine,
The dream of curing cancer by exploiting natural immunity goes back at least as far as the time of Paul Ehrlich, when the potential of the immune system was only a subject of speculation. Since then, having made substantial progress in understanding the molecular and cellular aspects of the immune system, we have begun to fulfill this dream -- at least for some patients. This book is not, however, about these clinical advances. Rather, it selectively explores emerging cellular and therapeutic approaches that may contribute to clinical advances over the next two decades. However, because the selection of topics is so random, the book lacks a predominant leitmotif that advances a specific hypothesis or concept. Investigational approaches to the identification of human tumor antigens with the use of cultured T cells or serologic analysis by recombinant expression cloning are described, but the analysis of genes and proteins and T-cell-receptor spectrotyping for this purpose are overlooked. Dendritic-cell vaccines are described, but peptide, anti-idiotypic, and allogeneic-cell vaccines are not. One of the early strategies used in clinical immunotherapy, bacterial vaccination, is well reviewed in the modern context of natural immunity through toll-like receptors. Interferons, also mediators of natural immunity, are mentioned in a good chapter on the regulation of the major histocompatibility complex. But no chapter covers the role of interferons in influencing antigen processing or immune effector-cell function or their therapeutic activity in both solid tumors and hematologic cancers. Although one whole chapter and part of another are devoted to interleukin-10, other cytokines (such as interleukin-2, interleukin-4, interleukin-12, and interleukin-18) merit only slight mention in the very complete and erudite chapters on transforming growth factor (beta) as an immunosuppressor and in a chapter on cytokines fused to antibodies. A chapter is devoted to preclinical investigations of monoclonal antibodies conjugated to chemical toxins, but there is no discussion of the clinically approved toxin ozogamicin conjugated to gemtuzumab. Other topics not included are the mechanism of the clinically effective engineered monoclonal antibodies (rituximab, ibritumomab, and alemtuzumab), two of which, rituximab and ibritumomab, are effective both alone and as radioimmunoconjugates. The editors of this monograph state that their goal is to review the "current understanding of tumor immunology with special emphasis on the inter-relationship of the tumor and immune system, and cancer immune therapy." A further understanding of the scientific basis of tumor immunology without a comprehensive clinical review is a worthwhile objective. But lessons can also be derived from a review of clinically effective approaches that may or may not yet have reached their full potential. On both counts, and because there are so many gaps in the selection of the subjects covered, this book should be valued mainly for the understanding it provides to readers interested in the individual topics. Jaroslaw Maciejewski, M.D., Ph.D.
http://rapidshare.de/files/16102298/Cancer_inmunoterapia.zip.html
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 | William D. Leslie, I. David Greenberg, "Nuclear Medicine
Landes Bioscience | ISBN 1570596441 | 2003 Year | DjVu | 5,37 Mb | 389 Pages
Manual includes radiation effects and safety, myocardial perfusion imaging, bone density, inflammatory disorders, tumor imaging, pediatric nuclear medicine, and more. Wire-spiral binding.
Vademecum Univ. of Manitoba, Winnipeg, Canada. Manual includes radiation effects and safety, myocardial perfusion imaging, bone density, inflammatory disorders, tumor imaging, pediatric nuclear medicine, and more. Wire-spiral binding.
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 | Diagnosis and Treatment of Lung Cancer 1st edition
An Evidence-Based Guide for the Practicing Clinician
by Frank C., M.D. Detterbeck
ISBN: 0721691927
This book is written for clinicians who are involved in the care of patients with lung cancer. This includes pulmonologists, thoracic surgeons, medical oncologists, radiation oncologists, primary care physicians, nurses, and others who desire insight into currently available data about the diagnosis and treatment of lung cancer. The focus of this book is on the practical issues that such clinicians face in their daily practice. In order to achieve this goal, the contributing authors chosen for this book were selected from a group of clinicians who are actively involved in caring for patients with lung cancer. In addition, all the authors are part of a multidisciplinary team that has worked together closely and grappled with clinical issues involving patients with lung cancer on a daily basis over the course of several years. We hope that this book is a useful and unbiased source of information that will contribute to improving the treatment of patients with lung cancer.
Access comprehensive, multidisciplinary guidance on the diagnosis and treatment of lung cancer! This new resource addresses the full range of clinical issues in diagnosis, staging, and treatment, as well as the latest scientific data and evidence-based guidelines. A user-friendly organization provides quick reference to data summaries, as well as more comprehensive and detailed information for readers who wish to explore topics in depth.
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The Chemotherapy Source Book 3rd edition
Author Michael C., Md. Perry (Editor)
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Cancer Chemotherapy and Biotherapy: Principles and Practice 3rd edition
Author: Bruce A. Chabner (Editor), Dan L. Longo (Editor)
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Principles & Practice of Pediatric Oncology
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Cancer - Principles & Practice of Oncology
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Oxford Textbook of Oncology
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Surgical Oncology
This book presents the most important information in surgical oncology in an easily accessible manner. It can be read during the length of a rotation on a surgical oncology service. Chapters are arranged by organ involvement. Each chapter begins with epidemiology and screening following by methods of diagnosis, preoperative evaluation and staging.
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Psychosocial Aspects of Pediatric Oncology
Publisher:John Wiley & Sons
Author: Shulamith Kreitler (Editor), Myriam Weyl Ben
Arush (Editor)
ISBN: 0471499390
From the New England Journal of Medicine, November 11, 2004
In this monograph, the editors have brought together 17 contributions that describe the intertwining medical, psychological, and social aspects of the study and care of children with cancer. In many ways it is an update and extension of Bearison and Mulhern's textbook, Pediatric Psychooncology (New York: Oxford University Press, 1994), in that it covers many of the same topics with some of the same authors. However, the contributors to the new book represent several nations, primarily Israel, whereas the Bearison and Mulhern book is written strictly by U.S. authors. As a result, the considerable overlap among the chapters allows the reader to recognize interesting international differences in thought and practice in regard to meeting the psychosocial needs of children with cancer and their families. For example, a chapter by a U.S. author states that more than half of children with progressive cancer die at home, whereas an Israeli contribution indicates that only rarely does the death of the child occur at home. Also, some authors leave it to the parents to decide whether or not the child should be told the diagnosis and prognosis. For me, the critical need for honesty with children was confirmed 40 years ago by Vernick and Karon in their landmark paper, "Who's Afraid of Death on a Leukemia Ward?" (American Journal of Diseases of Children 1965;109:393). Currently, in the United States, clinicians need to obtain informed consent of children older than seven years of age to register them in cancer studies, which leaves no option but candor. This entails patient, tactful discussion among the health care team, the child, and the family so that all can communicate openly. This book contains many outstanding discussions that are valuable to all who care for children with cancer. The chapters by Wolfe et al. on palliative care, Hain on pain control, and Postovsky and Ben Arush on "do not attempt to resuscitate" offer especially practical and useful information. Highly illuminating to me were the chapters on the role of fantasy, art therapies, humor, and pets and on complementary and alternative therapies. The lengthy, well-organized, detailed review of the measurement of the quality of life in children deserves to become a standard reference. Most representative of quantitative science is the chapter by Mulhern and colleagues on the neuropsychological sequelae of childhood cancer and its treatment. This chapter is based on a review of the literature and the extensive clinical studies that have been conducted at St. Jude Children's Research Hospital since 1970 -- the year we recognized that acute lymphoblastic leukemia was no longer an incurable disease. Some general statements in the introduction need to be modified. The first sentence says that cancer is the leading cause of death from disease in children past the neonatal period. Worldwide, malnutrition and infectious disease cause far more deaths.
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Principles and Practice of Pediatric_Oncology
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 | Cancer Management: A Multidisciplinary Approach: Medical, Surgical and Radiation Oncology
Written by 110 of the nation's leading oncologists, Cancer Management: A Multidisciplinary Approach is the recipient of unanimous praise from over 3,500 cancer specialists worldwide. A premier source of cancer information from stages 0-IV, this textbook details the very latest screening, diagnostic, staging, treatment, and outcomes for universal patient management.
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 | Manual of Clinical Oncology
Dennis Albert Casciato
Lippincott Williams & Wilkins
0781721598 750 pages
Book Description
This handy book is an invaluable guide to the diagnosis and treatment of cancer patients. Its clear and comprehensive outline format allows quick retrieval of essential information and provides informed choices in the difficult oncologic decision-making process. --This text refers to an out of print or unavailable edition of this title.
Book Info
Univ. of California, Los Angeles. Pocket outline to diagnosis and treatment includes data on principles of management, solid tumors, hematologic malignancies, and complications.
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Tropic of Cancer
ISBN: 0802131786
No punches are pulled in Henry Miller's most famous work. Still pretty rough going for even our jaded sensibilities, but Tropic of Cancer is an unforgettable novel of self-confession. Maybe the most honest book ever written, this autobiographical fiction about Miller's life as an expatriate American in Paris was deemed obscene and banned from publication in this country for years. When you read this, you see immediately how much modern writers owe Miller.
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Cell Cycle Inhibitors in Cancer Therapy: Current Strategies
ISBN: 0896039307
Publisher: Humana Press
Publication Date: 2002-12
Number Of Pages: 400
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 | Endocrine Tumors (Atlas of Clinical Oncology)
ISBN: 1550091344
Author: Orlo H. Clark Quan Y., M.D. Duh Nancy D., M.D. Perrier
Publisher: B.C. Decker
Publication Date: 2002-07-15
Number Of Pages: 300
Book review:
Information regarding the management of endocrine cancers of the thyroid, parathyroid, adrenal glands, pancreas, as well as carcinoid tumors.
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 | Plants that Fight Cancer
Spiridon E. Kintzios, "Plants that Fight Cancer"
CRC | ISBN 0415298539 | 2004 Year | PDF | 4,2 Mb | 312 Pages
Book review:
Invaluable for those engaged in cancer therapy or research, Plants that Fight Cancer is an extensive review of plant genera and species with documented anticancer properties. The current conclusions are described, along with conventional, advanced and alternative treatments for cancer. More than 150 plant genera and species are examined, including their distribution, botany, traditional usage, active ingredients and product applications, as well as expected results and risks. An analysis of algal extracts and isolated metabolites is included, as well as a summary of published research for each species. For experts, the chemical structures of the most important compounds are also listed.
Book Info
Agricultural Univ. of Athens, Greece. Provides an extensive survey of the plant genera and species having anti-tumor and anti-leukaemic properties. Explores the botany, traditional uses, active ingredients, toxicity, and documented target cancers as well as reviewing the latest findings for each genera. For researchers.
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 | Oncogenomics: Molecular Approaches to Cance
Cancer is not a single genetic disease but, rather, hundreds of diseases consisting of various combinations of genetic alterations. Many types of genetic alterations contribute to neoplastic transformation. The evidence for this statement has now become common knowledge. In a similar vein, almost everybody believes that genome sequencing is paving the way to a revolution in biology and medicine in general but in oncology in particular. We all mention imatinib and a few monoclonal antibodies when we want to demonstrate that targeted therapies are already more than just a vision. We are, however, still unable to foresee clearly the role genomics will play in the prevention, diagnosis, and treatment of cancer in the next 10 or 15 years. This uncertainty stems mainly from a dearth of clinical data, and most of the data we do have are retrospective and therefore most probably biased. As stated in its introduction, this book is probably the first of its kind devoted to the genomics of cancer. I approached it with mixed feelings: on the one hand, I was hoping to find answers to some of my questions, mainly because the span of the book reaches from molecular profiling to model systems for discovering and validating drug targets, and from molecularly targeted pharmacology to clinomics. The latter is a term coined by Daniel Von Hoff et al., whose chapter in this book defines clinomics as the application of genomics to patient care.
The essence of the book is to bring together scientists from various specialties and share the same language, a prerequisite for the next "leap forward." It seems logical that the book concludes with an essay by A.C. von Eschenbach, the director of the National Cancer Institute, who gives his vision of oncology in 2015. Franco Cavalli, M.D., F.R.C.P.
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The Clinician's Guide to Gastrointestinal Oncology
by Michael Kochman (Editor)
Paperback: 450 pages
Publisher: Slack Incorporated (May 15, 2005)
ISBN: 1556426828
Book Description
The Clinician's Guide to Gastrointestinal Oncology is a unique practical reference for the management of patients with gastrointestinal malignancies and pre-malignant conditions. The high incidence of colorectal cancer coupled with the growing recognition of Barrett's esophagus has led to a growing need for a resource explaining how to screen and manage these and other patients with gastrointestinal neoplasia.
Dr. Michael Kochman, with contributions from other recognized experts of diverse gastrointestinal backgrounds, uses a multidisciplinary approach in presenting the necessary information to optimally manage patients. A balanced approach allows the reader to quickly synthesize an individualized care plan based upon the recommendations of highly skilled professionals. Part of The Clinician's Guide to GI Series, this text also serves as a reference for clinicians to be able to quickly discuss the epidemiology and natural history of these conditions.
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Managing Breast Cancer Risk
by Monica Morrow, V. Craig Jordan
Book Description
Northwestern Univ., Chicago, IL. Discusses individual risk factors along with models integrating multiple factors allowing for more complete assessments. Addresses the evaluation of risk, risk management strategies, chemoprevention, and surgical prevention. Features both traditional and new approaches and considers quality of life and symptom management.
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Plants that Fight Cancer
Invaluable for those engaged in cancer therapy or research, Plants that Fight Cancer is an extensive review of plant genera and species with documented anticancer properties. The current conclusions are described, along with conventional, advanced and alternative treatments for cancer. More than 150 plant genera and species are examined, including their distribution, botany, traditional usage, active ingredients and product applications, as well as expected results and risks. An analysis of algal extracts and isolated metabolites is included, as well as a summary of published research for each species. For experts, the chemical structures of the most important compounds are also listed.
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 | Rectal Cancer : New Frontiers in Diagnosis, Treatment and Rehabilitation
Author: by Gian Gaetano Delaini (Editor)
ISBN: 8847003423
Publisher: Springer; 1 edition (April 17, 2006)
Format: PDF - 267 pages
Book Description
Despite lifestyle improvements, the incidence of rectal cancer is increasing in industrialised countries. Rapid advances in technology, growing knowledge of the biological history of the disease and closer attention to patients' quality of life after surgery have led to a less invasive approach. In the last 15 years, the surgical approach has shifted from extended resection to sphincter-saving procedures, featuring a multidiscipinary approach and a high level of specialisation. The experienced surgeon can plan and choose the "right treatment for the right patient" only with the support of the radiologist, endoscopist and pathologist (preoperative staging), oncologist and radiotherapist (neoadjuvant therapy), and psychologist and stomatherapist (rehabilitation). In addition, the difficult problems of salvage procedure and the reconstruction of anal sphincter after abdominal resection are explored. The aim of this book is to clarify the rapid advances and to offer guidelines for doctors dealing with rectal cancer. Taking into account indications, contraindications, risks, benefits and controversies, the authors offer clear and practice-oriented answers for a wide range of specialists and experts, as well as those new to the field.
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5.73 MB
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Clinical Trials in Oncology, 2nd Ed
size: 2.82 MB
- Includes new sections on Phase I design and array data
- Emphasizes the importance of proper design, management, and analysis
- Incorporates expanded discussions on competing risks, subset analyses, and randomized Phase IIs
- Contains further comments on prognostic factor analysis,
- Clearly describes complex exploratory analysis methods
The new edition of Clinical Trials in Oncology provides a concise, nontechnical, and now thoroughly up-to-date review of methods and issues related to clinical trials. The authors emphasize the importance of proper study design, analysis, and data management and identify the major pitfalls that are seemingly inherent in these processes. This edition includes a new section that describes recent innovations in Phase I designs. Another new section on microarray data examines the challenges presented by massive data sets and describes approaches used to meet those challenges. As always, the authors use clear, lucid prose and a multitude of real-world trials as examples to convey the principles of successful trials without the need for a strong statistics or mathematics background.
Although the book focuses on cancer trials, the issues and concepts are important in any clinical setting. Clinical Trials in Oncology, Second Edition works to improve the mutual understanding by clinicians and statisticians of the principles of clinical trials and helps them avoid the many hazards that can jeopardize the success of a trial.
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Advances in Radiation Oncology in Lung Cancer
Description
Although decades of laboratory and clinical research have led to incremental improvement in treatment outcome, lung cancer remains one of the most deadly diseases. This volume is unique in being devoted solely to the radiation oncology of lung cancer, and will be of great value to all who are involved in the diagnosis and treatment of the disease. Both non-small cell and small cell lung cancer are considered in detail. Current state-of-the-art treatment strategies and novel approaches that promise further improvements in outcome are explained and evaluated, with the aid of high-quality illustrations. Treatment-related toxicity is discussed, and further individual chapters focus on topics such as quality of life studies, prognostic factors and pitfalls in the design and analysis of clinical trials.
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Tumor Marker Protocols - Methods in Molecular Medicine
Pages: 500
A much-needed collection of cutting-edge methods for the detection and discovery of new cancer markers, particularly molecular tumor markers. Each method is fully described by a hands-on expert who regularly uses it in the laboratory and has perfected it to a high degree of ready reproducibility. Special emphasis is given to statistical considerations in the analysis of tumor markers, recent discoveries in the field of serum and tissue marker proteins, cytogenetic markers, molecular markers, and markers for the early detection of cancer. The well-honed procedures detailed here will enable cancer researchers and clinical oncologists alike to realize the promise of these powerful new diagnostic strategies for the detection, therapy, and successful prevention of cancer.
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Radioimmunotherapy of Cancer
Pages: 391
Reflecting the past 20 years of intense research in radioimmunotherapy, this timely reference surveys an expansive breadth of topics on the evolving developments in radiation therapy. Placed in the context of advances in cancer treatment, chapters progress systematically from basic principles and properties of radionuclides to detailed summaries of current cancer therapies.Up to date, clearly organized, and thorough-sure to become a standard in the field! antibody therapy, Radioimmunotherapy of Cancerreviews dosimetric principles and clinical dosimetry of radioimmunotherapy in the targeting and delivery of radiationdescribes tumor architectures and outlines novel constructs for radionuclide deliveryanalyzes a variety of improved targeting approaches, including pretargeting contextual analysis of extracorporeal techniques in radioimmunotherapydetails studies from the radiotherapy of lymphoma, solid tumors, and ovarian cancer and the targeted radiotherapy of neuroblastoma and squamous head and neck cancerand much more!With contributions from nearly 50 international experts and containing over 1300 literature references, drawings, photographs, tables, and equations, Radioimmunotherapy of Cancer is an invaluable and indispensable reference for physicians in nuclear medicine and medical physicists; oncologists, radiologists, radiochemists, and radiopharmacists; immunologists, pulmonologists, and cancer researchers; pharmacologists and drug delivery pharmaceutical chemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.
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